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So far I would say that this is a good medicine for RLS and I haven't had any side effects.
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Restless legs syndrome is a hard problem to deal with. Mirapex seems like a God send. But like most things it comes with a cost. First was the dollar cost which over the last 6 years has gone up considerably. The next price you pay is from side effects. Falling asleep while talking to someone is embarrassing and dangerous. But I've found a wonderful fix. While at the doctors I had to use a Doctor's Assistant (who was playing on her cell phone while talking to me). She gave me a prescription for Mirapex that is time released and you only take it at night just before bed time. My energy level has increased 10x and I don't fall asleep while dinning out with my wife. Blessed by Doctor%u2019s Assistant and her playing on the cell phone actually was searching on the intranet for something to help with the problem.

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Cases of pneumonia were defined by a first clinical diagnosis of severe community acquired pneumonia during cohort follow-up identified by a hospitalization for pneumonia or acute lower respiratory infection identified using ICD-10 codes.

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Pramipexole is a novel nonergot dopamine agonist which has high selectivity for interacting with dopamine D 2 receptors.

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Here is a collection of user reviews for the medication Mirapex ER sorted by most helpful.

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It is believed that the long duration of action of these drugs, as compared with levodopa, is the main reason for the less frequent development of dyskinesias and fluctuations in response.

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Pramipexole (Mirapex, Mirapexin, Sifrol) is a dopamine agonist of the non-ergoline class indicated for treating early-stage Parkinson's disease (PD) and restless legs syndrome (RLS).

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Other treatments may include acupuncture and herbal therapies, such as ginseng ( Panax ginseng) for anemia-related fatigue.

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This practice is known as off-label use.

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People with early-onset RLS (occurring in the teenage years or earlier) tend to have a family history of the disorder.

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Anxiety can cause agitation and leg restlessness that resemble RLS.

The information contained on (the "Site") is provided for informational purposes only and is not meant to substitute for advice from your doctor or health-care professional.

Treatment, as always, should be tailored to the needs of the individual.

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Pramipexole should be taken orally with or without food depending with the instructions that your doctor gives to you.

Mirapex could dangerously lower blood pressure.

People with Parkinson's disease may have an increased risk for developing skin cancer (melanoma).

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Do not stop taking except on your doctor's advice.

For example, pramipexole has been used (in combination with D 2- and or D 3-preferring antagonists) to interrogate the role of D 3 receptor function in rodent models and tasks for neuropsychiatric disorders.

WebMD understands that reading individual, real-life experiences can be a helpful resource, but it is never a substitute for professional medical advice, diagnosis, or treatment from a qualified health care provider.

Disease indicate that Mirapex is an anti-depressant as well, possibly even as effective as Prozac.

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Some people taking the medicine in pramipexole have had car accidents because they fell asleep while driving.

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It is used for the treatment of some types of malaria.

Tell your doctor or pharmacist if you are taking other products that cause drowsiness including alcohol, antihistamines (such as cetirizine, diphenhydramine), drugs for sleep or anxiety (such as alprazolam, diazepam, zolpidem), muscle relaxants (such as carisoprodol, cyclobenzaprine), and narcotic pain relievers (such as codeine, hydrocodone).

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The authors thank Dr Dorothee Bartels of Boehringer-Ingelheim AG for providing the results of the pooled analyses from the randomized trials of pramipexole.

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The follow-up time of the cohort members ended at the time of the occurrence of the first of the following events: a diagnosis of pneumonia, the 90th birthday, death, the end of the patient's registration with the practice or of the contribution of data by the general practice, or the end of the study period (June 30, 2009).

If stomach upset occurs, take with food to reduce stomach irritation.

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The most common adverse effects in people taking Mirapex for RLS are nausea and sleepiness.

They include sleep apnea, spinal cord injuries, stroke, narcolepsy, and diseases that destroy nerves or the brain over time.

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Pramipexol augmentation of a selective serotonin reuptake inhibitor in the treatment of depression.

Since the 1950s, it has been known that iron therapy, even without the presence of anemia has benefits for RLS symptoms.

You, your family, or your caregiver should call your doctor right away if you experience any of the following symptoms: panic attacks; agitation or restlessness; new or worsening irritability, anxiety, or depression; acting on dangerous impulses; difficulty falling or staying asleep; aggressive, angry, or violent behavior; mania (frenzied, abnormally excited mood); talking or thinking about wanting to hurt yourself or end your life; withdrawing from friends and family; preoccupation with death and dying; giving away prized possessions; or any other unusual changes in behavior or mood.

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It has been reported that falling asleep while engaged in activities of daily living usually occurs in a setting of pre-existing somnolence, although patients may not give such a history.

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Male or female patients aged at least 18 years.

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As the disease progresses, the shaking, or tremor, which affects the majority of people with PD may begin to interfere with daily activities.

When I mentioned to the Dr that I was gambling, he said "you're on Mirapex, stop taking it immediately".

Adding selegiline or a dopamine agonist may help.

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There are generic versions of short-acting pramipexole available, but these drugs are not equivalent to Mirapex ER.

That finding suggests that worsening of the condition is caused by dopamine agonists, not a natural occurrence, the study authors pointed out.

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You should consult with a medical professional if you have any questions about your health.

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Other supplements tried for leg cramps include vitamin E, calcium, and potassium or sodium chloride, but these do not appear to be very effective.

Practice Parameter: evaluation and treatment of depression, psychosis, and dementia in Parkinson disease (an evidence-based review): report of the Quality Standards Subcommittee of the American Academy of Neurology.

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