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Methotrexate works wonders for my psoriasis. I have been suffering from Psoriasis covering my hands since I remember myself. It is very painful and looks disgusting especially in exacerbation. My palms crack and bleed and people are afraid of communicating with me. In my life I have tried many topicals and other meds but only Methotrexate made me give a sigh of relief. I'm happy to have found it!
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I have been taking methotrexate for about 2 years for my rheumatoid arthritis. The medication helps me to decrease pain significantly and it does control inflammation. Some time ago I stopped taking it for 2 months because I would be able to go on without it, but my symptoms returned so I started taking it again. Great medication.

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Between 30 to 70 percent of people who have not benefitted from other rheumatoid arthritis medications experience some measure of relief from biologics.

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Contact your doctor right away if you develop symptoms such as fast or irregular heartbeat; fainting; decreased urination; muscle weakness or cramps; nausea, vomiting, diarrhea, or loss of appetite; or sluggishness.

For example, in a 48-week double-blind placebo-controlled trial of 434 individuals with active rheumatoid arthritis, use of folate helped prevent liver inflammation caused by methotrexate.

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FibroSpect, II (Prometheus Laboratories, San Diego, CA) and FibroSure (LabCorp, Burlington, NC) tests for liver fibrosis, although unproven to aid in the diagnosis of methotrexate-induced fibrosis, are available in the United States and could be considered as possible alternatives for patients in whom liver biopsy is technically difficult or contraindicated.

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If we find that the strategy of first adding hydroxychloroquine and sulfasalazine to MTX identifies a subset of responsive patients and that there is no harm to nonresponders because of early rescue with etanercept, then this less expensive option should become the standard treatment for MTX resistant patients.

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Improvement in the cutaneous disease activity of patients with dermatomyositis is associated with a better quality of life.

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NOTICE: This health information was not created by the University of Michigan Health System (UMHS) and may not necessarily reflect specific UMHS practices.

Stop taking methotrexate if you get diarrhea, or if you get sores in your mouth.

In conclusion, methotrexate represents an acceptable alternative to corticosteroids in patients with sarcoidosis.

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Patches are typically found on the elbows, knees, scalp, lower back, face, palms, and soles of feet, but can affect other places (fingernails, toenails, and mouth).

Generally, older people have osteoarthritis because their joints have been overused and simply become worn out.
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